The only FDA-approved medical therapy for Peyronie’s disease is collagenase clostridium histolyticum (Xiaflex). Clinical trials have shown that this drug degrades the scar tissue, improving penile curvature in the majority of men.
- A course of Xiaflex treatment is made up of four treatment cycles.
- One cycle of treatment involves two Xiaflex injections, 1-3 days apart.
- The patient is taught how to perform at-home “penile modeling” for 6 weeks following each cycle of injections.
- After the cycle of injections, patients are also taught how to use a penile traction device for 2 hours daily.
- Before resuming sexual activity, patients should wait at least four weeks after the second injection of each cycle.
Patients will be taught how to perform two different penile modeling techniques after each cycle of injections. The first is a stretching activity and the second is a straightening activity. These should be carried out for six weeks following each cycle of treatment.
- Penile stretching: This should be performed three times a day with a non-erect penis. An alternative to this would be to use the traction device for 2 hours a day.
- Penile straightening: This should be done maximum once per day and only if a spontaneous erection occurs.
- Grasp the penis by the tip (glans) and stretch it out.
- Bend the penis in the direction opposite of the curve, using the location of the plaque as the bending point.
- This stretch and bend should be held for 30 seconds and then released.
- Repeat this for a total of three times, with 30 seconds of rest in between.
- In rare instances, aggressive penile modeling can cause penile fracture. Please call our office and go to the emergency department if you experience the following symptoms after penile modeling:
- A popping sensation or sound
- Sudden loss of the ability to maintain an erection
- Blood in the urine or difficulty urinating
- Severe penile pain